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In the push and pull of crowds, disordered proteins dance precariously
intrinsically disordered proteins (IDPs) carry out a range of important biological tasks and play a key role in several biological functions. In collaboration scientists from RMIT and the CSIRO, research facilitated at the Australian Centre for Neutron Scattering and the National Deuteration Facility reveals how IDPs and their regions behave under various physiological processes.
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Deuterated ionic liquids
The favourable properties of ionic liquids make them useful for numerous applications.
High stability means ionic liquids are suitable for use as electrolytes in extreme environments such as space. The NDF have produced several selectively deuterated ionic liquids that have been used to increase our understanding of ionic liquids.
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Studying enzyme mechanisms using deuterated substrates
The NDF is providing deuterated substrates to enable researchers to study enzyme binding. This is important for designing enzymes for applications as drug targets and as biocatalysts.
These studies demonstrate the broadening user base for the National Deuteration Facility, with requests to synthesise deuterated molecules for neutron as well as non-neutron based applications.
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2022 Product Catalogue released
The National Deuteration Facility have released the 2022 Product Catalogue, click the link below to download.
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Insight into membrane fusion in COVID infection
ANSTO’s National Deuteration Facility has provided deuterated cholesterol for international research to gain a better understanding of how the Spike protein of the COVID virus, SARS-Co-V-2, infects human cells through a membrane fusion mechanism.
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Deuterated linoleic acid-d31: Available now
The NDF has achieved a concise and scalable synthesis to access gram quantities of linoleic acid-d31. The NDF’s expertise in phospholipid synthesis means that desirable linoleoyl lipids can now be synthesised on request.
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New type of nanoparticles for drug delivery
Monash University researchers have used advanced techniques at ANSTO to investigate the production of new, elongated polymer nanocapsules with a high payload of drug nanocrystals to potentially increase drug targetability, and also decrease dosage frequency and side effects.
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Supporting new areas of COVID research
ANSTO’s National Deuteration Facility has been providing high-quality deuterated lipids used in the construction of cell membrane models to support research that improves our understanding of how the virus interacts with elements of the cell membrane, a relatively new area of investigation.
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Enabling polymer research
The National Deuteration Facility has supported industry through the synthesis of deuterated mineral oil, which was supplied to Japanese chemical manufacturer Mitsui Chemicals.
Mitsui Chemicals specialises in polymeric materials for packaging, appliances, construction and other applications.
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Acknowledgements
The National Deuteration Facility is partly supported by the National Collaborative Research Infrastructure Strategy – an initiative of the Australian Government.
