Deuteration supports blood test to help diagnose breast cancer
The National Deuteration Facility has supplied deuterium labelled lipids to quantify lipid biomarkers in a blood test to help diagnose breast cancer.Find out more
New flow chemistry capability saves deuteration time with high yields
The National Deuteration Facility has developed a capability to use a flow chemistry process to increase efficiency, increase production capacity and reduce decomposition in the synthesis of deuterated molecules.Find out more
Enhancing characterisation capabilities at the NDF
The National Deuteration Facility has recently commissioned a new nuclear magnetic resonance (NMR) spectrometer to enhance characterisation capabilities.Find out more
Deuterated Plasmalogens: A New Class of Labelled Lipids from the NDF
The National Deuteration Facility has recently developed a successful synthetic route to access deuterium labelled plasmalogens, which are an important class of lipid for investigating lipid biology and implications for numerous diseases.
Studies in selective microbial deuteration for chiral molecules
This NDF-led study investigated development of potential cost-effective methods for reductive microbial deuteration (utilising yeast strains) to produce crucial chiral building blocks for medicinal and analytical applications with a high degree of isotopic labelling and enantioselectivity.Combining synthetic organic chemistry and microbes to perform enzymatic transformations allowed the enantioselective synthesis of important chiral molecules.
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2025 NDF Product Catalogue released
The National Deuteration Facility (NDF) has released their 2025 Product Catalogue, now containing almost 300 unique deuterated molecules.
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Manipulating a Thermosalient Crystal Using Selective Deuteration
Dr Alexander Angeloski of the National Deuteration Facility led a study published in JACS that demonstrated deuteration can manipulate the properties of a crystal that converts heat into mechanical motion.
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New flow chemistry capability to enhance NDF production capacity
The National Deuteration Facility has recently acquired a Vapourtec flow reactor integrates real-time monitoring, streamlined processing, and flexible productivity, thereby advancing the field of flow-based deuteration. These capabilities not only facilitate the adaptation of established batch processes to continuous flow for multigram-scale synthesis but also encourage the exploration of novel deuteration methodologies. This work is supported by NCRIS Uplift funding received in 2023 Phase 2 funding for expansion of existing capabilities and development of new capabilities.
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Enhancing the oxidative stability of squalene
The National Deuteration Facility has demonstrated the potential of deuteration for stabilisation of industrially relevant materials. An important proof of concept study showcases how the substitution of hydrogen atoms with the stable isotope deuterium can stabilise key cosmetic and medicinal product components.
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Acknowledgements
The National Deuteration Facility is partly supported by the National Collaborative Research Infrastructure Strategy – an initiative of the Australian Government.
