Animal and Human Ethics Approval Process - Australian Synchrotron

Animal Ethics

Experiments conducted at the Australian Synchrotron (AS) that involve the use of animals for research purposes  ethical approval from the AS Animal Ethics Committee (AS-AEC).  Live animal experimentation may be performed at the Imaging and Medical beamline (IMBL).

Post mortem tissue samples generated in a compliant and/or approved manner may be examined at any beamline at the AS, in accordance with the Experiment Authorisation procedures.

The Australian Synchrotron adheres to the Prevention of Cruelty to Animals Act 1986 and the Australian Code for the care and use of animals for scientific purposes 8th ed. 2013 via maintaining a Scientific Procedure Premises Licence (SPPL). 

 As such, all scientific procedures at the AS that involve the holding and usage of live animals at the AS, must be approved by the applicant's approved home institution animal ethics committee (AEC), where relevant, and by the Australian Synchrotron AEC, before the project can commence.

It must be noted that:

• Approval by the applicant's home institution AEC does not guarantee approval by the AS-AEC.
• Investigators who are not based at an Australian institute must ensure that their proposal for beamtime is accompanied by an application to the AS-AEC, but does not need to be accompanied by approval forms from their home institute.
• An approved AEC is one that is recognised under the Code for the care and use of animals for scientific purposes.

How and when to apply

The assessment of beamtime proposals and AEC applications occur concurrently, and successful beamtime proposals will only be scheduled once AEC approval is granted.  Owing to this, you are advised to submit your AEC application at the same time as your beamtime proposal.  

For applicants not familiar with Australian Ethics requirements or who are unfamiliar with the Australian Synchrotron Ethics process, application in advance of beam proposal submission is advised. 

Assistance in navigating the ethics process can be sought via [email protected]

 If AS-AEC approval is not acquired in time, the scheduling of your experiment may be rescheduled to the following beam round, pending the merit application raking highly enough in this round. 

It should be noted that beamtime proposal approval does not influence or have any bearing on the likelihood of ethics approval.

 Submission deadlines for beamtime proposals and AEC applications are shown below, under 'AEC Meeting Dates'.

1. Discuss your proposed experiment and animal holding requirements with the IMBL Scientist before submitting your beamtime proposal. 
2. When applying for beamtime, ensure that the check-box entitled “Will this proposal involve holding or usage of live animals on the Imaging and medical beamline at the Australian Synchrotron?” is selected.

3. A) 

   If your home institute has an approved AEC:

• Submit your home institute AEC application to [email protected], including the following information:                
  • the approved version of your approved home institute AEC application; 
  • any approved minor amendments that are relevant to the proposed experiments at the synchrotron; and
  • evidence of home institute approval of the original application and minor amendments.
• Post submission the AS AEC secretariat will seek  a relevant inter-committee agreement between the two organisations. 

• Please note that all beamtime proposals must be submitted to the AS AEC secretariat for approval, even when the work to be performed will be covered under an existing AS AEC approval. That is, the proposal number must be explicitly cited against an AS AEC approval number.

  3. b) 

  If the investigators' home institution is not in Australia, an AS-AEC application form must be completed and submitted to [email protected]. 

1. Subsequent minor amendments can be made using the AS Request for Amendment request form and submitted to [email protected]. 

AEC meeting dates

(Updated Dec - 2024)

2024

2025

Notification of ethics approval

 The AS-AEC will notify the Primary Investigator of the outcome of their AEC application within 4 weeks of the evaluation of the proposal.

Animal welfare

It is a requirement of the Australian Synchrotron AEC to report all expected and unexpected or adverse events regardless of whether the incident had a negative impact on animal welfare. All animal incidents must be reported within 48 hours using the AS-AEC animal incident report form and are to be submitted via [email protected]

Examples of animal incidents that must be reported include:

• death of an animal, or group of animals, that was not expected
• adverse effects following a procedure or treatment that was not expected
• adverse effects in a larger number of animals than predicted during the planning of the project or activity, based on the number of animals actually used, not the number approved for the study
• a greater level of pain or distress than was predicated in the planning of the project or activity
• power failures, inclement weather, emergency situation or other factors external to the project or activity that have a negative impact on the welfare of the animals
• experimental endpoint was not reached due to equipment failures, where animal welfare was not impacted
• substitution of approved brand of consumable or reagent that was specified in the application that was not available to use during the experiment, where animal welfare was not impacted.

Post experiment reporting

The Chief Investigator on the AEC application MUST submit an AS Animal Experiment Report within 2 weeks of completing the beamtime. Failure to submit the required reports by the stipulated deadline will lead to suspension of approval of the project. The Committee may also exercise its right to withhold approval for new applications while project reports on previously approved projects are outstanding

Chief Investigators must also provide the AEC with the following:

• an annual report for each project having active approval, regardless of the duration of AEC approval for the project
• a final report on outcomes as soon as practicable after completion or discontinuation of a project.

The continuation of all approved animal ethics projects is contingent upon the submission of annual reports to the AEC. The report will advise the AEC on:

• what progress has been achieved, and whether the project is meeting its aims
• any problems that may have interfered with progress of the project
• how many animals have been used
• whether the well-being of the animals is consistent with that anticipated in the proposal.

Annual project reports must be submitted by the 31st January of the following year using the AS-AEC Annual project report form.

Useful Links

• Australian Code for the care and use of animals for scientific purposes, 8th ed. 2013
• Guidelines for the ethical use of animals in research & teaching, agriculture Victoria
  These Guidelines contain information and resources to aid all persons involved in the use of animals in research and teaching in carrying out their responsibilities under the legislation.
• 3Rs implementation strategies and techniques
  Replacement - techniques that replace the use of animals must be sought and used where possible
  Reduction - each project must use no more than the minimum number of animals necessary and
  Refinement - projects should be designed to avoid pain and distress in animals.
• NHMRC Guidelines to Promote the Wellbeing of Animals Used For Scientific Purposes
• Best Practice Methodology in the Use of Animals for Scientific Purposes