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Chemical deuteration instrument laboratory
National Deuteration Facility

News and highlights

  • JACS journal cover

    Insight into membrane fusion in COVID infection

     

    ANSTO’s National Deuteration Facility has provided deuterated cholesterol for international research to gain a better understanding of how the Spike protein of the COVID virus, SARS-Co-V-2, infects human cells through a membrane fusion mechanism.

    FInd out more
  • Michael Moir in chemistry lab with chemical structure of deuterated linoleic acid

    Deuterated linoleic acid-d31: Available now

     

    The NDF has achieved a concise and scalable synthesis to access gram quantities of linoleic acid-d31. The NDF’s expertise in phospholipid synthesis means that desirable linoleoyl lipids can now be synthesised on request.

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  • A gloved hand holding a red capsule

    New type of nanoparticles for drug delivery

     

    Monash University researchers have used advanced techniques at ANSTO to investigate the production of new, elongated polymer nanocapsules with a high payload of drug nanocrystals to potentially increase drug targetability, and also decrease dosage frequency and side effects.

    Read more
  • cell surface

    Supporting new areas of COVID research

     

    ANSTO’s National Deuteration Facility has been providing high-quality deuterated lipids used in the construction of cell membrane models to support research that improves our understanding of how the virus interacts with elements of the cell membrane, a relatively new area of investigation.

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  • Contrast matching mineral oil

    Enabling polymer research

     

    The National Deuteration Facility has supported industry through the synthesis of deuterated mineral oil, which was supplied to Japanese chemical manufacturer Mitsui Chemicals.

    Mitsui Chemicals specialises in polymeric materials for packaging, appliances, construction and other applications. 

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  • vaccination

    Improving mRNA vaccines

     

    Recent international research involved the deuteration of cholesterol for lipid nanoparticles to improve mRNA drug delivery and vaccines.

    The National Deuteration Facility at ANSTO provided the biodeuterated cholesterol, which was used with small-angle neutron scattering, to gain structural insights into the composition of the lipid nanoparticles.

    Deuteration can also be used to enhance the metabolic properties of some biomolecules and the structural integrity of some materials.

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  • bacteria

    Research into protein structures

     

    ANSTO's National Deuteration Facility is the world's primary source in highly deuterated monoolein, one of the most important lipids in the fields of drug delivery, emulsion stabilization and protein crystallization.

    The supply of this molecule has enabled multiple researchers within Australia and internationally to utilise neutrons to investigate protein structures. Demand for this molecule from the national and international community continues to grow.

    Find out more
  • Shelves filled with files

    News archive

     

    To access past NDF News and Highlights, please access the page below.

    News archive

Acknowledgements

The National Deuteration Facility is partly supported by the National Collaborative Research Infrastructure Strategy – an initiative of the Australian Government.

NCRIS version 2